PODS® Human Wnt-1

The product contains the polyhedrin protein co-crystalized with Human Wnt-1. Wnt proteins constitute a large family of secreted proteins (sharing 20% to 85% aminoacid identity) with different roles in cell fate deciosion, axon guidance, and tumour formation. Wnt-1 is a secreted glycoprotein that binds members of the Frizzled family of cell surface receptors and plays a crucial role in the embryonic development and carcinogenesis. Wnt-1 signaling is responsible for stabilizing the intracellular signaling protein β-catenin. For certain cell lines, Wnt-1 supports self-renewal while keeping undifferentiated.