VPS11 blocking peptide Reference: GTX89450-PEP Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 4 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 28]
PODS® Mouse Activin A Reference: PPM29-250 The product contains the polyhedrin protein co-crystalized with Mouse Activin A. Activin A is a member of the Transforming Growth Factor beta (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin beta A chains. Mouse Activin A shares 100% amino acid sequence identity with human, rat, porcine, bovine, and feline Activin A proteins.
NHERF2 (isoform a) blocking peptide Reference: GTX89452-PEP This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 211]
PODS® Mouse Activin A Reference: PPM29-1000 The product contains the polyhedrin protein co-crystalized with Mouse Activin A. Activin A is a member of the Transforming Growth Factor beta (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin beta A chains. Mouse Activin A shares 100% amino acid sequence identity with human, rat, porcine, bovine, and feline Activin A proteins.
BAALC blocking peptide Reference: GTX89453-PEP This gene was identified by gene expression studies in patients with acute myeloid leukemia (AML). The gene is conserved among mammals and is not found in lower organisms. Tissues that express this gene develop from the neuroectoderm. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines. [provided by RefSeq, Jul 28]
PODS® Rat Activin A Reference: PPR6-50 The product contains the polyhedrin protein co-crystalized with Rat Activin A. Activin A is a member of the Transforming Growth Factor beta (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin beta A chains. Rat Activin A shares 100% amino acid sequence identity with human, mouse, porcine, bovine, and feline Activin A proteins.
HP1 gamma blocking peptide Reference: GTX89454-PEP At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 211]
PODS® Rat Activin A Reference: PPR6-250 The product contains the polyhedrin protein co-crystalized with Rat Activin A. Activin A is a member of the Transforming Growth Factor beta (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin beta A chains. Rat Activin A shares 100% amino acid sequence identity with human, mouse, porcine, bovine, and feline Activin A proteins.
CBX1 / HP1 beta blocking peptide Reference: GTX89455-PEP This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 28]
PODS® Rat Activin A Reference: PPR6-1000 The product contains the polyhedrin protein co-crystalized with Rat Activin A. Activin A is a member of the Transforming Growth Factor beta (TGF-β) family of proteins with a wide range of biological activities. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin beta A chains. Rat Activin A shares 100% amino acid sequence identity with human, mouse, porcine, bovine, and feline Activin A proteins.
PCID1 blocking peptide Reference: GTX89456-PEP This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 211]
PODS® Human Activin B Reference: PPH307-50 The product contains the polyhedrin protein co-crystalized with Human Activin B. Activin B is a member of the TGF-β superfamily, which are disulfide-linked dimeric proteins that were originally purified from gonadal fluids and had as primary role to stimulate the release of pituitary follicle stimulating hormones (FSH). Activin B has shown to have a wide range of biological activities including: mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, reproductive physiology, and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activins exert their biological activities through binding to the heterodimeric complex composed of two membrane spanning serine-threonine kinases designated as type I and type II. Two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B) have been identified. Activin B signals through the ActRII receptor (Activin Receptor type II).