Arginase 1 blocking peptide Reference: GTX89098-PEP Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 211]
Recombinant Human Pleiotrophin Reference: GFH55-1000 Pleiotrophin is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. Pleiotrophin is made by many tissues, but is predominantly secreted by nervous tissue during development. Pleiotrophin induces neurite outgrowth and is involved in tumor growth and metastasis. Pleiotrophin binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection and can also bind the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.
Arginase 1 blocking peptide Reference: GTX89099-PEP catalyzes the hydrolysis of arginine to ornithine and urea in arginine metabolism; regulates nitric oxide production [RGD, Feb 26]
Recombinant Human Pleiotrophin (Animal-Free) Reference: GFH55AF-5 Pleiotrophin is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. Pleiotrophin is made by many tissues, but is predominantly secreted by nervous tissue during development. Pleiotrophin induces neurite outgrowth and is involved in tumor growth and metastasis. Pleiotrophin binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection and can also bind the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.
FOXO4 blocking peptide Reference: GTX89101-PEP This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 21]
Recombinant Human Pleiotrophin (Animal-Free) Reference: GFH55AF-20 Pleiotrophin is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. Pleiotrophin is made by many tissues, but is predominantly secreted by nervous tissue during development. Pleiotrophin induces neurite outgrowth and is involved in tumor growth and metastasis. Pleiotrophin binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection and can also bind the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.
FOXO1 blocking peptide Reference: GTX89102-PEP This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 28]
Recombinant Human Pleiotrophin (Animal-Free) Reference: GFH55AF-100 Pleiotrophin is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. Pleiotrophin is made by many tissues, but is predominantly secreted by nervous tissue during development. Pleiotrophin induces neurite outgrowth and is involved in tumor growth and metastasis. Pleiotrophin binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection and can also bind the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.
KIAA1881 blocking peptide Reference: GTX89103-PEP Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 23 [PubMed 128423]).[supplied by OMIM, Feb 21]
Recombinant Human Pleiotrophin (Animal-Free) Reference: GFH55AF-1000 Pleiotrophin is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. Pleiotrophin is made by many tissues, but is predominantly secreted by nervous tissue during development. Pleiotrophin induces neurite outgrowth and is involved in tumor growth and metastasis. Pleiotrophin binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection and can also bind the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.
ILF2 blocking peptide Reference: GTX89104-PEP The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 9 kDa interleukin enhancer-binding factor 3 (NF9, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF9 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 214]
Recombinant Human PlGF-3 Reference: GFH198-5 Placenta Growth Factor (PlGF) is a member of the Vascular Endothelial Growth Factor (VEGF) / Platelet-Derived Growth Factor (PDGF) family of growth factors that share a conserved pattern of eight cysteines. PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues. These growth factors induce monocyte activation, migration, and production of inflammatory cytokines and VEGF. There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and heparin-binding affinities. PlGF-3 is an angiogenic factor, which promotes endothelial cell growth and angiogenesis, being expressed exclusively in the placenta.