SLC12A6 blocking peptide Reference: GTX88947-PEP This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 28]
Recombinant Human Myostatin / GDF-8 Reference: GFH22-1000 Myostatin, also known as GDF-8, a conserved member of the TGF-β superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA, ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.
PLA2G1B blocking peptide Reference: GTX88948-PEP This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 213]
Recombinant Human Myostatin Propeptide (Animal-Free) Reference: GFH142-5 Myostatin, also known as GDF-8, a conserved member of the TGF-β superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. The recombinant myostatin propeptide binds and inhibits myostatin to enhance the repair and regeneration of injured muscle and bone.
IGFBP3 blocking peptide Reference: GTX88951-PEP This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 28]
Recombinant Human Myostatin Propeptide (Animal-Free) Reference: GFH142-25 Myostatin, also known as GDF-8, a conserved member of the TGF-β superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. The recombinant myostatin propeptide binds and inhibits myostatin to enhance the repair and regeneration of injured muscle and bone.
Arylsulfatase A blocking peptide Reference: GTX88953-PEP The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 21]
Recombinant Human Myostatin Propeptide (Animal-Free) Reference: GFH142-100 Myostatin, also known as GDF-8, a conserved member of the TGF-β superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. The recombinant myostatin propeptide binds and inhibits myostatin to enhance the repair and regeneration of injured muscle and bone.
Nodal blocking peptide Reference: GTX88954-PEP The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 28]
Recombinant Human Myostatin Propeptide (Animal-Free) Reference: GFH142-1000 Myostatin, also known as GDF-8, a conserved member of the TGF-β superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. The recombinant myostatin propeptide binds and inhibits myostatin to enhance the repair and regeneration of injured muscle and bone.
Recombinant Human NGF-β Reference: GFH38-5 Nerve Growth Factor β (NGF-β) is a neurotrophic factor that is important for the development and maintenance of sensory and sympathetic neurons. NGF-β signals through the low affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase A (TrkA) to activate PI3K, Ras, and PLC signaling pathways. NGF-β is also involved in the growth, differentiation, and survival of B lymphocytes. Human, mouse, and rat NGF-β proteins are cross-reactive.