LASS1 blocking peptide Reference: GTX88587-PEP This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 28]
Recombinant Mouse IL-27 / p28 subunit (Animal-Free) Reference: GFM50AF-100 The p28 subunit of interleukin-27 (IL-27), also known as interleukin-30 (IL-30), is a member of the interleukin-12 (IL-12) family of cytokines. p28 is a 28 kDa polypeptide that associates with the Epstein-Barr virus induced gene 3 (EBI-3) to form the IL-27 cytokine heterodimer complex. IL-27 functions as a proinflammatory cytokine that induces immunomodulatory effects in naive CD4+ T cells, mast cells, and monocytes. p28 can also form a complex with Cytokine-Like Factor 1 (CLF), that is secreted by dendritic cells, to regulate Natural Killer (NK) and T cell function.
GluR4 blocking peptide Reference: GTX88589-PEP Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 28]
Recombinant Mouse IL-27 / p28 subunit (Animal-Free) Reference: GFM50AF-1000 The p28 subunit of interleukin-27 (IL-27), also known as interleukin-30 (IL-30), is a member of the interleukin-12 (IL-12) family of cytokines. p28 is a 28 kDa polypeptide that associates with the Epstein-Barr virus induced gene 3 (EBI-3) to form the IL-27 cytokine heterodimer complex. IL-27 functions as a proinflammatory cytokine that induces immunomodulatory effects in naive CD4+ T cells, mast cells, and monocytes. p28 can also form a complex with Cytokine-Like Factor 1 (CLF), that is secreted by dendritic cells, to regulate Natural Killer (NK) and T cell function.
Recombinant Human IL-29 Reference: GFH169-5 Interleukin-29 (IL-29), also known as IFN-lambda 1, is a type III interferon produced by virally infected cells. IL-29 plays an important role in host defenses against microbes and antiviral activity. IL-29 shares homology with interleukin-28 (IL-28) and binds the class II cytokine receptor IL-28R.
SPHK1 blocking peptide Reference: GTX88593-PEP The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 211]
Recombinant Human IL-29 Reference: GFH169-20 Interleukin-29 (IL-29), also known as IFN-lambda 1, is a type III interferon produced by virally infected cells. IL-29 plays an important role in host defenses against microbes and antiviral activity. IL-29 shares homology with interleukin-28 (IL-28) and binds the class II cytokine receptor IL-28R.
Recombinant Human IL-29 Reference: GFH169-100 Interleukin-29 (IL-29), also known as IFN-lambda 1, is a type III interferon produced by virally infected cells. IL-29 plays an important role in host defenses against microbes and antiviral activity. IL-29 shares homology with interleukin-28 (IL-28) and binds the class II cytokine receptor IL-28R.
MARCH10 blocking peptide Reference: GTX88596-PEP MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 27 [PubMed 176428]).[supplied by OMIM, Apr 21]
Recombinant Human IL-29 Reference: GFH169-1000 Interleukin-29 (IL-29), also known as IFN-lambda 1, is a type III interferon produced by virally infected cells. IL-29 plays an important role in host defenses against microbes and antiviral activity. IL-29 shares homology with interleukin-28 (IL-28) and binds the class II cytokine receptor IL-28R.