HSH2D blocking peptide Reference: GTX88192-PEP T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 18688) and a costimulatory signal provided primarily by CD28 (MIM 18676) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 23 [PubMed 1296172]).[supplied by OMIM, Mar 28]
Recombinant Mouse IL-5 (Animal-Free) Reference: GFM20AF-5 Interleukin-5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. Human and mouse IL-5 show cross-reactivity.
Recombinant Mouse IL-5 (Animal-Free) Reference: GFM20AF-25 Interleukin-5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. Human and mouse IL-5 show cross-reactivity.
ARMS2 blocking peptide Reference: GTX88195-PEP This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. [provided by RefSeq, Oct 28]
Recombinant Mouse IL-5 (Animal-Free) Reference: GFM20AF-100 Interleukin-5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. Human and mouse IL-5 show cross-reactivity.
Aconitase 2 blocking peptide Reference: GTX88196-PEP The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 28]
Recombinant Mouse IL-5 (Animal-Free) Reference: GFM20AF-1000 Interleukin-5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. Human and mouse IL-5 show cross-reactivity.
DENTT blocking peptide Reference: GTX88198-PEP This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 29]
Recombinant Human IL-6 Reference: GFH10-5 Interleukin-6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions and signals through the cell-surface type 1 cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.
STAP2 (aa391-403) blocking peptide Reference: GTX88199-PEP This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 28]
Recombinant Human IL-6 Reference: GFH10-20 Interleukin-6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions and signals through the cell-surface type 1 cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.