Recombinant Pandinus impeRator Pandinin-2

Disrupts cell membranes through formation of pores. Has strong antimicrobial activity against Gram-positive bacteria B.subtilis, S.epidermidis, E.faecalis and S.aureus. Is less active against Gram-negative bacteria P.aeruginosa and E.coli. Also increases efficacy of antibiotics (ampicillin, chloramphenicol, streptomycin, kanamycin, novobiocin) when tested against E.coli, probably by facilitating their incorporation into the bacteria. Possesses antifungal activity against C.albicans and hemolytic activity against human, sheep and pig erythrocytes.