Category: Proteins & Peptides

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FMRP blocking peptide

Reference: GTX31911-PEP

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-23 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 21]

FcγRIIb/CD32B (human, recombinant)

Reference: 31830-100

Source: Active recombinant human C-terminal His-tagged FcγRIIb expressed in CHO cells • Amino acids: 46-217 • MW: 20.8 kDa

FcγRIIb/CD32B (human, recombinant)

Reference: 31830-50

Source: Active recombinant human C-terminal His-tagged FcγRIIb expressed in CHO cells • Amino acids: 46-217 • MW: 20.8 kDa

CFTR blocking peptide

Reference: GTX31913-PEP

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN2, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 28]

CEACAM8/CD66b (human, recombinant)

Reference: 31834-100

Source: Active recombinant human C-terminal His-tagged CD66b expressed in HEK293 cells • Amino acids: 35-319 • MW: 32.8 kDa

ME1 blocking peptide

Reference: GTX31914-PEP

This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 28]

CEACAM8/CD66b (human, recombinant)

Reference: 31834-50

Source: Active recombinant human C-terminal His-tagged CD66b expressed in HEK293 cells • Amino acids: 35-319 • MW: 32.8 kDa

ME2 blocking peptide

Reference: GTX31915-PEP

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 29]

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