IFN-β (human, recombinant) Reference: 31528-5 Source: Active recombinant human IFN-β expressed in CHO cells • Amino acids: 22-187 • MW: 20 kDa
B-Raf blocking peptide Reference: GTX31881-PEP This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 28]
IFN-β (human, recombinant) Reference: 31528-500 Source: Active recombinant human IFN-β expressed in CHO cells • Amino acids: 22-187 • MW: 20 kDa
PRAS40 blocking peptide Reference: GTX31882-PEP AKT1S1 is a proline-rich substrate of AKT (MIM 16473) that binds 14-3-3 protein (see YWHAH, MIM 11358) when phosphorylated (Kovacina et al., 23 [PubMed 12524439]).[supplied by OMIM, Mar 28]
SARS-CoV-2 Surface Glycoprotein S1 Subunit Reference: 31814-100 Source: Active recombinant C-terminal mouse IgG1 Fc-tagged SARS-CoV-2 surface glycoprotein S1 subunit expressed in HEK293 cells • Amino acids: 16-685 • MW: 101.4 kDa
Estrogen Receptor alpha blocking peptide Reference: GTX31883-PEP This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 214]
SARS-CoV-2 Surface Glycoprotein S2 Subunit Reference: 31815-100 Source: Recombinant C-terminal mouse IgG1 Fc-tagged SARS-CoV-2 surface glycoprotein S2 subunit expressed in insect cells • Amino acids: 686-1,213 • MW: 84.3 kDa
beta 2 Microglobulin blocking peptide Reference: GTX31884-PEP This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 214]
SARS-CoV-2 nsp16 Methyltransferase Reference: 31816-100 Source: Recombinant C-terminal His-tagged SARS-CoV-2 nsp16 methyltransferase expressed in E. coli • Amino acids: 6799-7096 • MW: 33.5 kDa
TFPI blocking peptide Reference: GTX31885-PEP This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 28]
SARS-CoV-2 Papain-like Protease Reference: 31817-100 Source: Active recombinant SARS-CoV-2 N-terminal His-tagged papain-like protease expressed in E. coli • Amino acids: 1,564-1,880 • MW: 36.8 kDa
Osteopontin blocking peptide Reference: GTX31886-PEP The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 211]