Category: Proteins & Peptides

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SLUG blocking peptide

Reference: GTX31749-PEP

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 28]

PDCD4 blocking peptide

Reference: GTX31750-PEP

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 21]

Thrombin (human)

Reference: 13188-1

Source: Human blood; all source material tested and found non-reactive to ,HTLV-III and HBsAg using FDA approved assay methods • Mr: 38 kDa

Nicastrin blocking peptide

Reference: GTX31751-PEP

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 28]

Thrombin (human)

Reference: 13188-250

Source: Human blood; all source material tested and found non-reactive to ,HTLV-III and HBsAg using FDA approved assay methods • Mr: 38 kDa

Nicastrin blocking peptide

Reference: GTX31752-PEP

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 28]

PRMT6 (human recombinant, baculovirus expressed)

Reference: 13866-50

Source: Recombinant N-terminal His-tagged protein expressed in Sf21 cells • Mr: 43.7 kDa • PRMT6 is a nuclear type-1 PRMT, catalyzing the formation of ω-NG-monomethylarginine and asymmetric ω-NG,NG-dimethylarginine on both histone and non-histone targets. Non-histone targets of PRMT6 include the nuclear high-mobility group (HMG) protein HMGA1a, a protein important in several processes relating to the maintainence of DNA integrity.

LKB1 blocking peptide

Reference: GTX31753-PEP

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 28]

TP53BP1 tudor-like region (human recombinant)

Reference: 14073-100

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli • Mr: 42.6 kDa • This product contains the tudor domain of TP53BP1. Binding of TP53BP1 to dimethylated lysine 382 on p53 (p53 K382me2), as well as histone H4K20me2, through the tudor domain, has been shown to be important for TP53BP1 localization to DNA double strand breaks.

Blimp1 blocking peptide

Reference: GTX31755-PEP

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 28]

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