PAK2 blocking peptide Reference: GTX31742-PEP The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 28]
BRDT bromodomain 1 (human, recombinant) Reference: 11548-100 Source: Recombinant N-terminal GST-tagged protein expressed in E. coli • Mr: 40.6 kDa • BRDT is similar to the RING3 protein family and possesses 2 bromodomain motifs and a PEST sequence motif, which is a region rich in proline (P), glutamic acid (E), serine (S), and threonine (T) residues known to have a short intracellular half-life.
PAK2 blocking peptide Reference: GTX31743-PEP The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 28]
NCOR2/SMRT (human recombinant) Reference: 11633-50 Source: 50 µg of recombinant N-terminal GST-tagged protein expressed in E. coli • Mr: 39 kDa • NcoR2 is a transcriptional corepressor that plays an essential role in the regulation of development and metabolism. HDACs can mediate nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands.
SHP2 blocking peptide Reference: GTX31744-PEP The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 212]
BRDT bromodomain 2 (human recombinant) Reference: 11649-100 Source: Recombinant N-terminal GST-tagged protein expressed in E. coli • Mr: 41.2 kDa • BRDT shares homology with the RING3 protein. The two bromodomains of BRDT recognize acetylated histone H4. Loss of BRDT leads to defects in spermatogenesis. In addition to testis specific expression, BRDT was found in approximately 20% of non-small cell lung cancers.
SHP2 blocking peptide Reference: GTX31745-PEP The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 212]
BRD4 bromodomain 1 (human, recombinant, His-tagged) Reference: 11720-100 Source: Recombinant N-terminal His-tagged BRD4 bromodomain 1 expressed in E. coli • Amino acids: 49-170 (partial protein) • MW: 16.6 kDa
PKR blocking peptide Reference: GTX31746-PEP The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 211]
BRD4 bromodomain 2 (human, recombinant, His-tagged) Reference: 11721-1 Source: Recombinant N-terminal His-tagged BRD4 bromodomain 2 expressed in E. coli • Amino acids: 342-460 (partial length) • MW: 15.8 kDa
SLUG blocking peptide Reference: GTX31748-PEP This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 28]