JMJD2D Strep-tagged (human recombinant) Reference: 11300-100 Source: Active recombinant N-terminal Strep II-tagged protein expressed in E. coli • Mr: 42.6 kDa • JMJD2D catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me2/3), leading to transcriptional repression and activation, respectively. JMJD2D is an α-ketoglutarate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity. Therefore this protein is purified by Strep-Tactin affinity chromatography.
ASK1 blocking peptide Reference: GTX31728-PEP Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 28]
Irisin (human recombinant) Reference: 11451-100 Source: recombinant protein expressed in E. coli. An N-terminal His-tag and SUMOpro tag were removed by cleavage with SUMO protease 1 (Ulp1). • Mr: 12.4 kDa
ATF6 blocking peptide Reference: GTX31729-PEP This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 211]
Thioredoxin 1 from E. coli (oxidized form) Reference: 11517-2 Source: one ampoule contains 2 mg thioredoxin from E. coli · Mr: 11.7 kDa
LSD1 blocking peptide Reference: GTX31730-PEP This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 29]
Thioredoxin 1 (human recombinant) Reference: 11518-250 Source: one ampoule contains recombinant human thioredoxin 1
beta Actin blocking peptide Reference: GTX31732-PEP This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 28]
Thioredoxin 1 (human mutant C61S/C72S) Reference: 11520-250 Source: Recombinant mutant human C61S/C72S thioredoxin 1 · Activity: C31 and C34
Cyclin O blocking peptide Reference: GTX31734-PEP This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 21396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes.[provided by RefSeq, Nov 21]
Thioredoxin 1 (mouse, recombinant) Reference: 11521-100 Source: One ampoule contains 100 µg of salt-free recombinant mouse cytosolic thioredoxin · Activity: fully active with mammalian thioredoxin reductase
Cyclin O blocking peptide Reference: GTX31735-PEP This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 21396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 term is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes.[provided by RefSeq, Nov 21]