CXCR3 blocking peptide Reference: GTX31566-PEP This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL1/IP1 (interferon-g-inducible 1 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 211]
Thioredoxin 1 (human recombinant) Reference: 11518-1,2 Source: one ampoule contains recombinant human thioredoxin 1
TRPV4 blocking peptide Reference: GTX31567-PEP This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 21]
Mouse Macrophage Microsomal Immunoblot Control Reference: 10004910-1 Cyclooxygenase 2 (COX-2) is a 72 kDa protein that has been cloned from a variety of species including human, mouse, rat, and ovine. This preparation of COX-2 microsomes was prepared by solubilization and dilution of the 100,000 x g pellet from the lysate of cytokine-stimulated mouse macrophage cultures. Cayman’s preparation of mouse macrophage microsomes is a ready-to-use sample for SDS-PAGE. As such, it is an excellent positive control for the following Cayman Chemical polyclonal antibodies: Item Nos. 160106, 160126, 160116, and 101750.
MP1 blocking peptide Reference: GTX31568-PEP This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 211]
OLIG2 blocking peptide Reference: GTX31569-PEP This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 28]
Prostaglandin D Synthase (hematopoietic-type, human recombinant) Reference: 10006593-100 Source: Active human recombinant N-term His-tagged protein expressed in E. coli · MW: 24.3 kDa · One unit of enzyme produces one µmole of PGD2/min at 25°C in 100 mM Tris-HCl buffer, pH 8.0, containing 1 mM GSH, 1 mg/ml magnesium chloride, and 40 µM PGH2
IFIT1 blocking peptide Reference: GTX31570-PEP This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 1 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 212]