vitamin D binding protein precursor (353-363) [Homo sapiens] Reference: A1099-5 Highly polymorphic serum glycoprotein
NALP2 blocking peptide Reference: GTX31277-PEP NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 6817) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 633). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 23 [PubMed 12563287]).[supplied by OMIM, Mar 28]
vitamin D binding protein precursor (353-363) [Homo sapiens] Reference: A1099-10 Highly polymorphic serum glycoprotein
TLR2 blocking peptide Reference: GTX31279-PEP The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 28]
vitamin D binding protein precursor (353-363) [Homo sapiens] Reference: A1099-25 Highly polymorphic serum glycoprotein
Bcl-G blocking peptide Reference: GTX31280-PEP The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 29]
CARD14 blocking peptide Reference: GTX31281-PEP This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL1, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 212]
ALS2CR2 blocking peptide Reference: GTX31282-PEP This gene encodes a protein that belongs to the serine/threonine protein kinase STE2 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 211]