NALP2 blocking peptide

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 6817) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 633). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 23 [PubMed 12563287]).[supplied by OMIM, Mar 28]