Defibrase®

Defibrase® is the trademark registered by Pentapharm for its Active Pharmaceutical Ingredient (API) Batroxobin, a serine protease. Batroxobin is a thrombin-like enzyme purified from the snake venom of Bothrops moojeni. Batroxobin is a pure single-chain glycopeptide with a molecular weight of approx. 32’600 Dalton. In contrast to thrombin, which converts fibrinogen into fibrin by splitting off fibrinopeptides A and B, batroxobin only splits off fibrinopeptide A. The enzyme has a defibrinogenating effect and is used clinically for the treatment of thrombotic diseases.