Recombinant Mouse CXCL2/MIP-2 Protein

C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It wasoriginally identified as a heparin-binding protein secreted from a murine macrophage cell line in response toendotoxin stimulation. The expression of mouse MIP-2 is stimulated by endotoxin. The mouse MIP-2 sharesapproximately 63% aa sequence identity with murine KC, another mouse alpha chemokine, which is inducedby PDGF. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs.Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidativeburst. The expression of MIP-2 was found to be associated with neutrophil influx in pulmonary inflammationand glomerulonephritis, suggesting that MIP-2 may contribute to the pathogenesis of inflammatory diseases.