Recombinant Mouse IL-4RA/CD124 Protein

Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to thetype I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions asreceptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgEproduction and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RAcan signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed byinitial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immunecells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R canalso interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.