Quote Recombinant Human Izumo sperm-egg fusion protein 1(IZUMO1),partial
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion . The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
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Reference:
CSB-EP812903HU_20
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