Quote Recombinant Mouse Dedicator of cytokinesis protein 8(Dock8),partial
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP (By similarity). Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing
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Reference:
CSB-EP807451MO1_1
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