Quote Recombinant Escherichia coli Hygromycin-B 4-O-kinase(hph)
The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.
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Reference:
CSB-EP365448ENLa0_200
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