Recombinant Mouse IL-17F - 25 µg

IL-17F, also known as C87042, is a homodimeric protein that is a member of the IL-17 family of cytokines produced by activated T cells and monocytes (1). IL-17F can stimulate production of other cytokines such as IL-6, IL-8 and G-CSF as well as regulate cartilage matrix turnover by increasing matrix release and inhibiting new matrix synthesis (2). It is an important regulator of inflammatory responses that functions differently than IL-17 in immune responses and diseases (3). IL-17F inhibits the angiogenesis of endothelial cells and induces endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1 (4). Skin biopsy samples from psoriasis patients show the upregulation of IL-17F expression (5).