Recombinant Human CD30 Ligand - 50 µg

The CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a type II transmembrane glycoprotein of the tumor necrosis factor ligand superfamily (1). CD30L is expressed on the cell surface of activated T cells, B cells, stimulated monocyte-macrophages, granulocytes, eosinophils and some Burkitt-like lymphoma cell lines (2). Recombinant CD30L has been shown to co-stimulate T cells and to act as a mitogen for Hodgkin's disease derived cell lines (3). The receptor for CD30L is a type I cytokine receptor that is highly expressed by activated T cells, Hodgkin and Reed- Sternberg (H-RS) cells, and anaplastic large cell lymphoma cells (4). CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis (5).