Recombinant Human IL-29 - 25 µg

Interleukin-29 (IL-29), also known as IFN-λ1, is a cytokine distantly related to type I interferons and the IL-10 family. It exerts its biological effects through a receptor that also binds IL-28A and IL-28B.2 This receptor is a heterodimeric class II cytokine receptor that consists of IL-10RB and IL-28RA. IL-29 activities overlap those of type I IFNs and include anti-viral activity and up-regulation of MHC class I antigen expression.3 The expression of IL-29 is induced by virus infection or double-stranded RNA. Upon binding to the receptor, it also induces JAK kinase activation and phosphorylation of STAT and STAT2.4 IL-28 and IL-29 have recently been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells.5