Quote CD279 [PD-1] (human)-muIg Fusion Protein
Human CD279 (PD-1; Programmed Cell Death 1) is a 55 kD Ig superfamily member with similarity to CD28 and CD152 (CTLA-4). It is expressed on activated T and B and myeloid cells and engagement by its ligands PD-L1 (CD274; B7-H1) or PD-L2 (B7-DC) can inhibit proliferation and cytokine expression. In mice blockade of PD-1 ligand interaction has been used to augment T cell anti-cancer responses.
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Reference:
ANC-549-020
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