Quote CD252 [OX40L] (human)-muCD8 Fusion Protein
Human CD252 (CD134L; OX40 ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells. CD252 binds to CD134 present on activated T cells, providing a costimulatory signal. Blockade of this interaction in mouse abrogated immunological effects in several models of inflammation and rejection. CD252-muCD8 fusion protein binds to CD134 positive cells in flow cytometry.
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Reference:
ANC-512-020
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