Quote SIGIRR (human):Fc (human) (rec.)
SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.
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Reference:
AG-40A-0093T-C010
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