NOL3 peptide

Nucleolar protein 3 (Nop3) is coded by the Arc gene. The nuclear isoform of Nop3 (1/Nop3)may be involved in RNA splicing and the cytoplasmic isoform (2/Myp) may inhibit apoptosis. Isoform 1 oligomerizes and binds to SFRS9/SRp3C and also interacts with NPM1. Isoform 2 binds caspase 2, caspase 8 and CED3 and inhibits caspase 8 activity. Nop3 isoform 1 is found in nucleoli and nucleoplasm. Nop3 isoform 2 is cytoplasmic. Nop3 is highly expressed in heart and skeletal muscle with lower levels detected in placenta, liver, kidney and pancreas