FBXL12 blocking peptide

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 4-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 61434), cullin (see CUL1; MIM 63134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 24 [PubMed 1552277]).[supplied by OMIM, Mar 28]

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