Apc10 blocking peptide
ANAPC1 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 64147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 11694) (summary by Wendt et al., 21 [PubMed 11524682]).[supplied by OMIM, Feb 211]
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Reference:
GTX17067-PEP
Brand: