Quote Human Topoisomerase I protein, His tag
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 2 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 28]
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Reference:
GTX01335-pro-S
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