Ginsenoside Rb3

A steroid glycoside with diverse biological activities; inhibits OGD-induced JNK-mediated activation of NF-κB and apoptosis in H9c2 mouse cardiac myoblasts; reduces myocardial apoptosis and production of ROS in a rat model of myocardial ischemia-reperfusion injury at 20 mg/kg; prevents increases in serum creatinine, BUN, MDA, and decreases in SOD activity and GSH levels, as well as inhibits renal cell apoptosis in a mouse model of cisplatin-induced nephrotoxicity at 10 and 20 mg/kg; decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer; decreases immobility time in the forced swim and tail suspension tests in mice