Sultriecin

A fungal metabolite; active against a panel of 15 fungal strains (MICs = 0.8-50 μg/ml); cytotoxic to B16/F10, HCT116, Moser, P388, A549, and K562 cancer cells (IC50s = 37.7, 1.92, 0.85, 3.8, 4.14, and 0.67 μg/ml, respectively); inhibits RNA and protein synthesis in L1210 leukemia cells (IC50s = 5.5 and 2.4 μg/ml, respectively); increases survival time in a B16/F10 syngeneic mouse melanoma model and a P388 murine leukemia model from 0.1-10 mg/kg