2',3',5'-Triacetyluridine

A prodrug of uridine; decreases neurodegeneration in the piriform cortex and striatum, as well as reduces the amount of huntingtin-positive aggregates and increases BDNF protein levels in the piriform cortex in a transgenic mouse model of Huntington’s disease at 6% in the diet; improves rotarod performance and increases survival in transgenic mouse models of Huntington’s disease; reverses toxicity and increases survival in a mouse model of DPD deficiency-induced 5-FU overdose at 2,000 mg/kg three times per day beginning within 24 hours of 5-FU administration