Ingenol-3-angelate

Specific protein kinase C (PKC) activator [1]. Selective activator of PKC isoforms, like PKCtheta in T cells [1, 5, 8]. Antiproliferative and proapoptotic (necrotic) [2, 3, 5]. Immunostimulant [6]. Chemotherapeutic [4, 6]. Anticancer compound [2, 3, 5]. Efficacious agent against actinic keratosis [7]. Antileukemic [8].