Prochlorperazine (maleate)

A dopamine D2 receptor antagonist; binds to rat recombinant D2 receptors (Ki = 4.7 nM); binds to D2 in rat striatal membranes (Ki = 2.9 nM); binds to rat recombinant D3 receptors (Ki = 35 nM); binds to the 5-HT3 receptor in N1E-115 mouse neuroblastoma cell membranes (Ki = 1.2 μM); increases the latency to paw licking in a hot plate test at 2 mg/kg, indicating analgesia; inhibits apomorphine-induced emesis in dogs (ED50 = 0.34 mg/kg),