Amifostine thiol (hydrochloride)

A radioprotective agent and an active metabolite of amifostine; scavenges ABTS radicals in a cell-free assay; prevents γ-radiation-induced single- and double-stranded DNA breaks, as well as inhibits γ-radiation induced mutations at the HGPRT locus in V79-B310H lung fibroblast cells at 4 mM; reduces cis-DDP-induced mutations at the HGPRT locus in V79-B310H cells; increases survival, reduces the loss of bone marrow progenitor cells, and inhibits decreases in intestinal collagen thickness and crypt and Paneth cell density in mice exposed to total body γ-irradiation at 500 mg/kg prior to irradiation