Quote CaMKII (Phospho-Thr286/Thr287) Monoclonal Antibody (Clone 22B1)
Antigen: mouse recombinant CaMKII • Host: mouse, clone 22B1 • Isotype: IgG1 • Cross Reactivity: (+) rat CaMKII • Application(s): ELISA, IF, IP, and WB • CaMKII functions in neural synaptic stimulation and T-cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.
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Reference:
10011438-100
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