Von Hippel Lindau antibody

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 28]
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Reference:
GTX32968
Brand:
Product Details
GTX32968

Data sheet

Size
100μl
Conjugation
Unconjugated
Host
Rabbit
Clonality
Polyclonal
Reactivity
Human, Mouse, Rat
Application
WB, ICC/IF, IHC-P
URL - Product
https://www.genetex.com/Product/Detail/Von-Hippel-Lindau-antibody/GTX32968

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