Quote SETDB2 antibody [N1], N-term
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 61128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 23 [PubMed 1275451]).[supplied by OMIM]
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Reference:
GTX108086
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