VAM1 antibody [N1], N-term

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 6114), ZO1-like (see TJP1; MIM 619), p55-like (see MPP1; MIM 3536), and LIN2-like (see CASK; MIM 3172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 21 [PubMed 11311936]).[supplied by OMIM]