G protein alpha Inhibitor 1 antibody

Guanine nucleotide-binding proteins (G proteins) form a large family of signal-transducing molecules. They are found as heterotrimers made up of alpha, beta, and gamma subunits. Members of the G protein family have been characterized most extensively on the basis of the alpha subunit, which binds guanine nucleotide, is capable of hydrolyzing GTP, and interacts with specific receptor and effector molecules. The G protein family includes Gs (MIM 13932) and Gi, the stimulatory and inhibitory GTP-binding regulators of adenylate cyclase; Go, a protein abundant in brain (GNAO1; MIM 139311); and transducin-1 (GNAT1; MIM 13933) and transducin-2 (GNAT2; MIM 13934), proteins involved in phototransduction in retinal rods and cones, respectively (Sullivan et al., 1986 [PubMed 392218]; Bray et al., 1987 [PubMed 311783]). Suki et al. (1987) [PubMed 244724] concluded that the human genome contains at least 3 nonallelic genes for alpha-i-type subunits of G protein; see, e.g, GNAI2 (MIM 13936), GNAI3 (MIM 13937), and GNAIH (MIM 13918).[supplied by OMIM]