Cofilin 2 antibody

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 88436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 69114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 146119]; Maciver and Hussey, 22). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 22 [PubMed 1189832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 22 [PubMed 1191171]).[supplied by OMIM]