Category: Antibodies

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Reference: HY-P99689

Lecanemab (BAN-2401) is an IgG1 anti-soluble aggregated amyloid beta (Aβ) monoclonal antibody. Lecanemab shows activity across oligomers, protofibrils and insoluble fibrils. Lecanemab can be used for the research of Alzheimer's Disease.

Reference: 10214-1

Immunogen: Synthetic peptide from the C-terminal region of human Nrf2 protein • Host: Rabbit • Species Reactivity: (+) Human, mouse, rat • Cross Reactivity: N/A • Applications: FC, ICC, IF, WB • MW = 90 kDa

Reference: HY-P99760

Nurulimab (BCD-145) is an anti-cytotoxic T lymphocyte antigen-4 (anti-CTLA-4) humanized monoclonal antibody. Nurulimab can be can be used in research of melanoma.

Reference: ARG30260

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Reference: 10218-1

Immunogen: Purified human recombinant PCSK9 • Host: Mouse • Clone: 15A6 • Isotype: IgG1 • Species Reactivity: (+) Human recombinant PCSK9 • Application: WB

Reference: HY-P99638

Gefurulimab (ALXN-1720) is a human-derived bispecific antibody against complement C5 and albumin that binds C5 and blocks its activation.

Reference: HY-P99325

Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research.