TRAIL-R1 to -R4 Flow Cytometry Pack Reference: AG-44B-0004 TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-kappaB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
One-step DNA Library Prep Kit for Illumina (1 ng Input DNA) Reference: K1255-24 Direct and rapid library construction of purified DNA samples by transposase
One-step DNA Library Prep Kit for Illumina (1 ng Input DNA) Reference: K1255-96 Direct and rapid library construction of purified DNA samples by transposase
One-step DNA Library Prep Kit for Illumina (5 ng Input DNA) Reference: K1256-24 Direct and rapid library construction of purified DNA samples by transposase
One-step DNA Library Prep Kit for Illumina (5 ng Input DNA) Reference: K1256-96 Direct and rapid library construction of purified DNA samples by transposase
One-step DNA Library Prep Kit for Illumina (for 50 ng DNA) Reference: K1257-24 Direct and rapid library construction of purified DNA samples by transposase
One-step DNA Library Prep Kit for Illumina (for 50 ng DNA) Reference: K1257-96 Direct and rapid library construction of purified DNA samples by transposase
DNA Library Quantification Kit for Illumina Reference: K1258-500 suitable for DNA libraries quantification for Illumina using the dye qPCR method.
EnhancedFasL, Soluble (human) (rec.) Pack Reference: AG-44B-0001 FasL, Soluble (human) (rec.) induces apoptosis in a concentration range of <1ng/ml in the presence of 0.1 to 1µg/ml of TNF Ligands Enhancer (Prod. No. AG-35B-0001). (Optimal conditions must be determined individually for each cell line tested)
EnhancedTRAIL, Soluble (human) (rec.) Pack Reference: AG-44B-0002 Induces apoptosis in a concentration range of 5-50ng/ml in the presence of 1µg/ml of TNF Ligands Enhancer (Prod. No. AG-35B-0001).
Ultra Filter Unit (MW cut off 10kDa) Reference: JAI-OPF-010E Ultra filter unit for serum pretreatment. Cut-off MW is 10kDa for serum 8-OHdG.
IDO1 (human) Enzyme+Inhibitor Set Reference: AG-44B-0006 IDO1 is a heme-containing enzyme that catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway, causing depletion of tryptophan which can lead to halted growth of microbes as well as T cells. IDO1 is an immune checkpoint protein, that plays a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation and antioxidant activity. The IDO1 (human) Enzyme+Inhibitor Set contains the active enzyme IDO1 (human) (rec.) (His) (AG-40B-0161), compound MMG-0358 (AG-CR1-3630), a very potent and specific inhibitor of IDO1, and protocols that can be used for IDO1 enzyme activity and IDO1 inhibition experiments. Both components can be used in vitro: • For cell culture to study the effect of hIDO1 in a cellular system.• For screening assay to search for new inhibitors of hIDO1.