Category: Reagents

Reference: 9003088-5
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A positive-gating modulator of IKCa1/KCa3.1 channels (EC50 = 109 nM); selective for KCa3.1 over KCa2.1, KCa2.2 and KCa2.3 (EC50s = 8,700, 6,800, and 4,400 nM, respectively), KCa1.1 as well as voltage-gated potassium...
Reference: 9003088-500
€0.00 (tax incl.)
A positive-gating modulator of IKCa1/KCa3.1 channels (EC50 = 109 nM); selective for KCa3.1 over KCa2.1, KCa2.2 and KCa2.3 (EC50s = 8,700, 6,800, and 4,400 nM, respectively), KCa1.1 as well as voltage-gated potassium...
Reference: 9003096-100
€0.00 (tax incl.)
An anticancer nucleoside analog; inhibits the growth of HL-60 promyelocytic leukemia cells (LC50 = 40 nM); inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and...
Reference: 9003096-25
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An anticancer nucleoside analog; inhibits the growth of HL-60 promyelocytic leukemia cells (LC50 = 40 nM); inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and...
Reference: 9003096-50
€0.00 (tax incl.)
An anticancer nucleoside analog; inhibits the growth of HL-60 promyelocytic leukemia cells (LC50 = 40 nM); inhibits the growth of MX-1 mammary, CX-1, HC-1, GC3, and VRC5 colon, LX-1, Calu-6, and NCI-H460 lung, and...
Reference: 9003137-10
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A partial agonist of the androgen receptor; activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors at 0.1 μM; induces expression of FKBP51 and FGF18 in HEK293 cells at...
Reference: 9003137-100
€0.00 (tax incl.)
A partial agonist of the androgen receptor; activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors at 0.1 μM; induces expression of FKBP51 and FGF18 in HEK293 cells at...
Reference: 9003137-50
€0.00 (tax incl.)
A partial agonist of the androgen receptor; activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors at 0.1 μM; induces expression of FKBP51 and FGF18 in HEK293 cells at...
Reference: 9003143-1
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A CFTR potentiator; increases forskolin-induced opening of wild-type and mutant CFTRs expressing the F508del and G551D missense mutations with EC50 values of 88, 3, and 339 nM, respectively, in a reporter assay;...
Reference: 9003143-10
€0.00 (tax incl.)
A CFTR potentiator; increases forskolin-induced opening of wild-type and mutant CFTRs expressing the F508del and G551D missense mutations with EC50 values of 88, 3, and 339 nM, respectively, in a reporter assay;...
Reference: 9003143-25
€0.00 (tax incl.)
A CFTR potentiator; increases forskolin-induced opening of wild-type and mutant CFTRs expressing the F508del and G551D missense mutations with EC50 values of 88, 3, and 339 nM, respectively, in a reporter assay;...
Reference: 9003143-5
€0.00 (tax incl.)
A CFTR potentiator; increases forskolin-induced opening of wild-type and mutant CFTRs expressing the F508del and G551D missense mutations with EC50 values of 88, 3, and 339 nM, respectively, in a reporter assay;...
Reference: 9003202-1
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A stilbene derivative with antioxidant and anticancer activities; stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM); reduces hydrogen peroxide-induced release of LDH in and increases...
Reference: 9003202-10
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A stilbene derivative with antioxidant and anticancer activities; stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM); reduces hydrogen peroxide-induced release of LDH in and increases...
Reference: 9003202-25
€0.00 (tax incl.)
A stilbene derivative with antioxidant and anticancer activities; stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM); reduces hydrogen peroxide-induced release of LDH in and increases...
Reference: 9003202-5
€0.00 (tax incl.)
A stilbene derivative with antioxidant and anticancer activities; stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM); reduces hydrogen peroxide-induced release of LDH in and increases...
Reference: 9003247-1
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A prodrug form of gemcitabine; enters cells through passive diffusion; inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50s = 35, 30, 60, and 40 nM, respectively); reduces tumor growth in...
Reference: 9003247-10
€0.00 (tax incl.)
A prodrug form of gemcitabine; enters cells through passive diffusion; inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50s = 35, 30, 60, and 40 nM, respectively); reduces tumor growth in...
Reference: 9003247-5
€0.00 (tax incl.)
A prodrug form of gemcitabine; enters cells through passive diffusion; inhibits the growth of L1210, CEM, MP-2, and BxPC-3 cancer cells in vitro (IC50s = 35, 30, 60, and 40 nM, respectively); reduces tumor growth in...
Reference: 9003370-50
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For screening a variety of terpenes; contains ~95 terpenes in a 96-well Matrix™ tube rack format as 10 mM stock solutions in DMSO; contains a diverse group of natural products with assorted biological activities and...
Reference: 9003415-1
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A macrocyclic trichothecene mycotoxin; induces cleavage of caspase-3 and PARP in HL-60 cells at 40 nM; cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml); intranasal administration...
Reference: 9003415-5
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A macrocyclic trichothecene mycotoxin; induces cleavage of caspase-3 and PARP in HL-60 cells at 40 nM; cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml); intranasal administration...
Reference: 9003415-500
€0.00 (tax incl.)
A macrocyclic trichothecene mycotoxin; induces cleavage of caspase-3 and PARP in HL-60 cells at 40 nM; cytotoxic to HepG2, Hep-2, Caco-2, A204, U937, and Jurkat cells (IC50s = 2.2-9.7 ng/ml); intranasal administration...
Reference: 9003456-10
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An acyl choline; inhibits protein kinase C activity at 100 μM; induces hemolysis in rat erythrocytes; plasma levels are decreased in female patients with ME/CFS
Reference: 9003456-25
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An acyl choline; inhibits protein kinase C activity at 100 μM; induces hemolysis in rat erythrocytes; plasma levels are decreased in female patients with ME/CFS
Reference: 9003456-5
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An acyl choline; inhibits protein kinase C activity at 100 μM; induces hemolysis in rat erythrocytes; plasma levels are decreased in female patients with ME/CFS
Reference: 9003474-1
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An isoprenoid with anticancer activity; induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes from 1-20 µM; induces apoptosis in Huh7 cells via loss of the mitochondrial...
Reference: 9003474-250
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An isoprenoid with anticancer activity; induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes from 1-20 µM; induces apoptosis in Huh7 cells via loss of the mitochondrial...
Reference: 9003474-5
€0.00 (tax incl.)
An isoprenoid with anticancer activity; induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes from 1-20 µM; induces apoptosis in Huh7 cells via loss of the mitochondrial...
Reference: 9003474-500
€0.00 (tax incl.)
An isoprenoid with anticancer activity; induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes from 1-20 µM; induces apoptosis in Huh7 cells via loss of the mitochondrial...
Reference: 9003475-1
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An NSAID and COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases PGE2 levels in paw tissue in a mouse model of...
Reference: 9003475-100
€0.00 (tax incl.)
An NSAID and COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases PGE2 levels in paw tissue in a mouse model of...
Reference: 9003475-250
€0.00 (tax incl.)
An NSAID and COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases PGE2 levels in paw tissue in a mouse model of...
Reference: 9003475-500
€0.00 (tax incl.)
An NSAID and COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2); prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases PGE2 levels in paw tissue in a mouse model of...
Reference: 9003530-1
€0.00 (tax incl.)
A nucleotide and dual P2Y2 and P2Y4 receptor agonist (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors); selective for P2Y2 and P2Y4 receptors over P2Y6...
Reference: 9003530-100
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A nucleotide and dual P2Y2 and P2Y4 receptor agonist (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors); selective for P2Y2 and P2Y4 receptors over P2Y6...
Reference: 9003530-5
€0.00 (tax incl.)
A nucleotide and dual P2Y2 and P2Y4 receptor agonist (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors); selective for P2Y2 and P2Y4 receptors over P2Y6...
Reference: 9003530-500
€0.00 (tax incl.)
A nucleotide and dual P2Y2 and P2Y4 receptor agonist (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors); selective for P2Y2 and P2Y4 receptors over P2Y6...
Reference: 9003569-1
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An intermediate alanine metabolite of remdesivir
Reference: 9003569-500
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An intermediate alanine metabolite of remdesivir
Reference: 9003598-100
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A ketone ester with anti-obesity and anticonvulsant activities; reduces body weight, food intake, and whole animal adiposity in mice fed an isocaloric diet; increases the seizure threshold and blood levels of...
Reference: 9003598-25
€0.00 (tax incl.)
A ketone ester with anti-obesity and anticonvulsant activities; reduces body weight, food intake, and whole animal adiposity in mice fed an isocaloric diet; increases the seizure threshold and blood levels of...
Reference: 9003598-50
€0.00 (tax incl.)
A ketone ester with anti-obesity and anticonvulsant activities; reduces body weight, food intake, and whole animal adiposity in mice fed an isocaloric diet; increases the seizure threshold and blood levels of...
Reference: 9003627-10
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A quinolone alkaloid; active against HCV (IC50 = 1.4 µg/ml) and L. gongylophorus; inhibits TPA- and A23187-induced NFAT activation in Jurkat cells but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50s = 3.44...
Reference: 9003627-25
€0.00 (tax incl.)
A quinolone alkaloid; active against HCV (IC50 = 1.4 µg/ml) and L. gongylophorus; inhibits TPA- and A23187-induced NFAT activation in Jurkat cells but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50s = 3.44...
Reference: 9003627-5
€0.00 (tax incl.)
A quinolone alkaloid; active against HCV (IC50 = 1.4 µg/ml) and L. gongylophorus; inhibits TPA- and A23187-induced NFAT activation in Jurkat cells but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50s = 3.44...
Reference: 9003627-50
€0.00 (tax incl.)
A quinolone alkaloid; active against HCV (IC50 = 1.4 µg/ml) and L. gongylophorus; inhibits TPA- and A23187-induced NFAT activation in Jurkat cells but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50s = 3.44...
Reference: 90084-1
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A potent CB1 and CB2 receptor agonist (Kis = 0.58-5 and 0.69-2.8 nM for human recombinant CB1 and CB2, respectively); considerably more potent than Δ9-THC in both behavioral tests and in receptor binding assays;...
Reference: 90084-10
€0.00 (tax incl.)
A potent CB1 and CB2 receptor agonist (Kis = 0.58-5 and 0.69-2.8 nM for human recombinant CB1 and CB2, respectively); considerably more potent than Δ9-THC in both behavioral tests and in receptor binding assays;...
Reference: 90084-25
€0.00 (tax incl.)
A potent CB1 and CB2 receptor agonist (Kis = 0.58-5 and 0.69-2.8 nM for human recombinant CB1 and CB2, respectively); considerably more potent than Δ9-THC in both behavioral tests and in receptor binding assays;...
Reference: 90084-5
€0.00 (tax incl.)
A potent CB1 and CB2 receptor agonist (Kis = 0.58-5 and 0.69-2.8 nM for human recombinant CB1 and CB2, respectively); considerably more potent than Δ9-THC in both behavioral tests and in receptor binding assays;...
Reference: 90262-10
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A structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus, and the amide of vanillylamine and oleic acid; acts as an agonist at TRPV1, inducing desensitization...
Reference: 90262-25
€0.00 (tax incl.)
A structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus, and the amide of vanillylamine and oleic acid; acts as an agonist at TRPV1, inducing desensitization...
Reference: 90262-5
€0.00 (tax incl.)
A structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus, and the amide of vanillylamine and oleic acid; acts as an agonist at TRPV1, inducing desensitization...
Reference: 90262-50
€0.00 (tax incl.)
A structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus, and the amide of vanillylamine and oleic acid; acts as an agonist at TRPV1, inducing desensitization...
Reference: 90510-1
€0.00 (tax incl.)
O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing T. brucei, the...
Reference: 90510-10
€0.00 (tax incl.)
O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing T. brucei, the...
Reference: 90510-5
€0.00 (tax incl.)
O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing T. brucei, the...
Reference: 92350-100
€0.00 (tax incl.)
A terpene alkaloid; induces inward currents in HEK293 cells expressing rat TRPV1 (EC50 = 0.64 µM at neutral pH); decreases LPS-induced PGE2 production, as well as reduces LPS- and IFN-induced NO release in isolated...
Reference: 92350-1
€0.00 (tax incl.)
A terpene alkaloid; induces inward currents in HEK293 cells expressing rat TRPV1 (EC50 = 0.64 µM at neutral pH); decreases LPS-induced PGE2 production, as well as reduces LPS- and IFN-induced NO release in isolated...
Reference: 92350-250
€0.00 (tax incl.)
A terpene alkaloid; induces inward currents in HEK293 cells expressing rat TRPV1 (EC50 = 0.64 µM at neutral pH); decreases LPS-induced PGE2 production, as well as reduces LPS- and IFN-induced NO release in isolated...
Reference: 92350-500
€0.00 (tax incl.)
A terpene alkaloid; induces inward currents in HEK293 cells expressing rat TRPV1 (EC50 = 0.64 µM at neutral pH); decreases LPS-induced PGE2 production, as well as reduces LPS- and IFN-induced NO release in isolated...
Reference: 92355-10
€0.00 (tax incl.)
A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 µg/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in...
Reference: 92355-100
€0.00 (tax incl.)
A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 µg/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in...
Reference: 92355-5
€0.00 (tax incl.)
A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 µg/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in...
Reference: 92355-50
€0.00 (tax incl.)
A terpene alkaloid; active against a variety of bacteria and C. albicans (MICs = 0.6-10 µg/ml); scavenges DPPH and ABTS radicals in cell-free assays; increases LC3-II and catalase levels and reduces ROS production in...
Reference: M1040-100
€0.00 (tax incl.)
This product is the methyl ester of the ω-5 fatty acid myristoleic acid. Myristoleic acid is a natural but uncommon fatty acid produced from myristic acid by the Δ9-desatuase enzyme. When esterified with cetyl alcohol...
Reference: M1067-1
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Ceramide trihexoside (CTH) is a glycosphingolipid found mostly in mammalian cell membranes. It is involved in cellular signaling and has been identified as a receptor for various toxins including shiga toxins and...
Reference: M1067-10
€0.00 (tax incl.)
Ceramide trihexoside (CTH) is a glycosphingolipid found mostly in mammalian cell membranes. It is involved in cellular signaling and has been identified as a receptor for various toxins including shiga toxins and...
Reference: M1071-1
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beta-tocopherol is one of the forms of vitamin E, which is well known for its antioxidant activity.1,2 beta-tocopherol, due to its having only one methyl group ortho to the phenolic hydroxyl group, has slightly less...
Reference: M1072-1
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Alpha-tocopherol is one of the eight forms of vitamin E and contains three methyl groups attached to the chromonal ring. Of all the forms of vitamin E, alpha-tocopherol is preferentially retained by the liver in...
Reference: M1073-1
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gamma-Tocopherol is the most prevalent form of vitamin E in many seed oils and is the major form of vitamin E in the U.S. diet. gamma-Tocopherol has greater functionability in some processes than other forms of...
Reference: M1074-1
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This synthetic product is very similar in structure to tocopherol (vitamin E) and tocotrienol but is not found naturally and is therefore an ideal MS, HPLC, and GC internal standard for tocopherols and tocotrienols.1...
Reference: M1155-100
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This high purity omega-9 very long-chain fatty acid is ideal as a standard and for biological studies. Nervonic acid is a fatty acid that is found in significant amounts in nerve tissue where it has many critical...
Reference: M1157-100
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This high purity myristoleic acid is ideal as a standard and for biological studies. Myristoleic acid is a natural but uncommon fatty acid produced from myristic acid by the delta-9-desatuase enzyme. When esterified...
Reference: M1161-100
€0.00 (tax incl.)
This high purity fatty acid is ideal as a standard and for biological studies. Odd numbered fatty acids occur in small amounts in mammals but are found in much larger amounts in bacteria and in some plants and lower...
Reference: M1165-100
€0.00 (tax incl.)
This high purity undecanoic acid is ideal as a standard and for biological studies. Odd numbered fatty acids occur in small amounts in mammals but are found in much larger amounts in bacteria and in some plants and...
Reference: M1207-50
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D,L-2,6-Dimethylheptanoic acid is a simple natural product derived in animal tissues from the metabolism of phytol by the oxidation of phytanic acid which results in the formation of 2,6-dimethylheptanoic acid along...
Reference: M1236-25
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Sterculic acid is a monounsaturated fatty acid containing a cyclopropene ring, which gives it specific and unusual physiological properties. The major sources of sterculic acid are the seed oils of various plants,...
Reference: M1243-25
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Hexadecenoic acid (cis-6) is an unusual unsaturated fatty acid that is the major constituent of human sebaceous lipids, from which it derives its common name sapienic acid, where it is involved in self-sterilization...
Reference: M1513-500
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Ceramide trihexoside is a glycosphingolipid found mostly in mammalian cell membranes. It is involved in cellular signaling and has been identified as a receptor for various toxins including shiga toxins and shiga-like...
Reference: M1514-500
€0.00 (tax incl.)
Ceramide trihexoside (CTH) is a glycosphingolipid found mostly in mammalian cell membranes. It is involved in cellular signaling and has been identified as a receptor for various toxins including shiga toxins and...
Reference: M1719-100
€0.00 (tax incl.)
This product is a glucosylceramide synthase inhibitor, an enzyme that is essential for the synthesis of a very large number of different glycolipids that are found in many organisms.1 PDMP has four possible isomers...
Reference: M1720-100
€0.00 (tax incl.)
This product is a glucosylceramide synthase inhibitor, an enzyme that is essential for the synthesis of a very large number of different glycolipids that are found in many organisms. PPMP has four possible isomers due...
Reference: M1731-25
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This 3-hydroxydodecanoic acid is a high purity standard that is useful for the investigation of disorders and diseases. Polyhydroxyalkenoates, polyesters produced by bacteria fermentation, are used for carbon and...
Reference: M1736-25
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This methyl 3-hydroxytetradecanoate is a high purity standard that is useful for the investigation of disorders and diseases. Polyhydroxyalkenoates, polyesters produced by bacteria fermentation, are used for carbon...
Reference: M1749-10
€0.00 (tax incl.)
This product is a glucosylceramide synthase inhibitor, an enzyme that is essential for the synthesis of a very large number of different glycolipids that are found in many organisms.1 PDMP has four possible isomers...
Reference: M1753-100
€0.00 (tax incl.)
This product is the erythro isomer of the glucosylceramide synthase inhibitor D-threo-PPMP. Whereas D-threo- PPMP is an active inhibitor both D- and L-erythro-PPMP are inactive towards glucosylceramide synthase and...
Reference: M1755-100
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This product inhibits the growth of cells, including cancer cells. D-threo-PDMP has been shown to inhibit cell growth by inhibiting the enzyme glucosylceramide synthase1 but erythro-PDMP inhibits growth according to a...
Reference: M1756-10
€0.00 (tax incl.)
This product is a glucosylceramide synthase inhibitor, an enzyme that is essential for the synthesis of a very large number of different glycolipids that are found in many organisms.1 PDMP has four possible isomers...
Reference: M1761-25
€0.00 (tax incl.)
This odd numbered omega-hydroxy heptadecanoic acid methyl ester is ideal as an internal standard for studies involving medium to long-chain omega-hydroxy fatty acids.1 omega-Hydroxy C17:0 fatty acid and other...
Reference: M1790-1
€0.00 (tax incl.)
delta-Tocopherol is one of the forms of vitamin E and in animal tissues has been found to have much less retention than alpha-tocopherol.1 Due to its having only one methyl group meta to the phenolic hydroxyl group...
Reference: M1797-1
€0.00 (tax incl.)
This synthetic product is very similar in structure to tocopherol (vitamin E) and tocotrienol but is not found naturally and is therefore an ideal MS, HPLC, and GC internal standard for tocopherols and tocotrienols.1...
Reference: M1802-25
€0.00 (tax incl.)
Sphingosine is a characteristic structural unit of many sphingolipids such as ceramides, gangliosides, globosides, sulfatides, sphingomyelin, and others.1,2 It is most abundant in nervous tissue and cell membranes....
Reference: M1806-10
€0.00 (tax incl.)
L-threo-Sphingosine is an inactive or less active isomer of the naturally occurring D-erythro-sphingosine. Natural sphingosine induces dephosphorylation of retinoblastoma gene products and inhibits cell growth while...

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