Category: Reagents

Reference: 10004372-50
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An inhibitor of p53-Mdm2 interaction (IC50 = 0.09 µM); induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53
Reference: 10004386-1
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A non-selective inhibitor of both COX-1 and COX-2 with extensive epidemiology documenting its effective reduction of human colorectal cancer
Reference: 10004386-10
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A non-selective inhibitor of both COX-1 and COX-2 with extensive epidemiology documenting its effective reduction of human colorectal cancer
Reference: 10004386-5
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A non-selective inhibitor of both COX-1 and COX-2 with extensive epidemiology documenting its effective reduction of human colorectal cancer
Reference: 10004386-50
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A non-selective inhibitor of both COX-1 and COX-2 with extensive epidemiology documenting its effective reduction of human colorectal cancer
Reference: 10004387-1
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A metabolite of sulindac that inhibits both COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); also inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and...
Reference: 10004387-10
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A metabolite of sulindac that inhibits both COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); also inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and...
Reference: 10004387-25
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A metabolite of sulindac that inhibits both COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); also inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and...
Reference: 10004387-5
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A metabolite of sulindac that inhibits both COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); also inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and...
Reference: 10004412-1
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A purine derivative; induces differentiation or dedifferentiation, depending on cell type; inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM; A3 receptor antagonist (Ki = 0.66 µM); inhibits MPS1...
Reference: 10004412-10
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A purine derivative; induces differentiation or dedifferentiation, depending on cell type; inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM; A3 receptor antagonist (Ki = 0.66 µM); inhibits MPS1...
Reference: 10004412-25
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A purine derivative; induces differentiation or dedifferentiation, depending on cell type; inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM; A3 receptor antagonist (Ki = 0.66 µM); inhibits MPS1...
Reference: 10004412-5
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A purine derivative; induces differentiation or dedifferentiation, depending on cell type; inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM; A3 receptor antagonist (Ki = 0.66 µM); inhibits MPS1...
Reference: 10004675-1
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The oxidized form of NADPH; serves as a cofactor in various biological reactions
Reference: 10004675-100
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The oxidized form of NADPH; serves as a cofactor in various biological reactions
Reference: 10004675-250
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The oxidized form of NADPH; serves as a cofactor in various biological reactions
Reference: 10004675-50
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The oxidized form of NADPH; serves as a cofactor in various biological reactions
Reference: 10004888-100
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A partial agonist of PPARγ; activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone; improves insulin resistance in normal, diet-induced...
Reference: 10004888-25
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A partial agonist of PPARγ; activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone; improves insulin resistance in normal, diet-induced...
Reference: 10004888-50
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A partial agonist of PPARγ; activates PPARγ with a lower potency (Ki = 15 versus 0.035 µM) but a similar maximal efficacy compared to rosiglitazone; improves insulin resistance in normal, diet-induced...
Reference: 10004914-1
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A cannabidiol (CBD) analog that acts as a selective antagonist of abnormal CBD (Abn-CBD) at the non-CB1/CB2 endothelial receptor; does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the...
Reference: 10004914-10
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A cannabidiol (CBD) analog that acts as a selective antagonist of abnormal CBD (Abn-CBD) at the non-CB1/CB2 endothelial receptor; does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the...
Reference: 10004914-25
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A cannabidiol (CBD) analog that acts as a selective antagonist of abnormal CBD (Abn-CBD) at the non-CB1/CB2 endothelial receptor; does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the...
Reference: 10004914-5
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A cannabidiol (CBD) analog that acts as a selective antagonist of abnormal CBD (Abn-CBD) at the non-CB1/CB2 endothelial receptor; does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the...
Reference: 10004971-10
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A selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively; at 10 µM, blocks the hydrolysis of cis- and trans-EETs and completely inhibits 14,(15)-EET-induced PPAR...
Reference: 10004971-25
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A selective sEH inhibitor with IC50 values of 160 and 90 nM for recombinant human and mouse sEH, respectively; at 10 µM, blocks the hydrolysis of cis- and trans-EETs and completely inhibits 14,(15)-EET-induced PPAR...
Reference: 10004974-1
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A selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to...
Reference: 10004974-10
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A selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to...
Reference: 10004974-25
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A selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to...
Reference: 10004974-5
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A selective calcium ionophore that mobilizes intracellular calcium stores. It is used as a research tool to raise the intracellular level of calcium, to study calcium transport across biological membranes, and to...
Reference: 10004976-10
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A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1
Reference: 10004976-25
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A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1
Reference: 10004976-5
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A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1
Reference: 10004985-1
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A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~7 µM); promotes the growth of HCT-116 cells ~20% at concentrations at or below 1 µM
Reference: 10004985-10
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A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~7 µM); promotes the growth of HCT-116 cells ~20% at concentrations at or below 1 µM
Reference: 10004985-5
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A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~7 µM); promotes the growth of HCT-116 cells ~20% at concentrations at or below 1 µM
Reference: 10005002-1
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A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~8 µM); promotes the growth of HCT116 cells ~40% at concentrations between 5-100 nM
Reference: 10005002-10
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A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~8 µM); promotes the growth of HCT116 cells ~40% at concentrations between 5-100 nM
Reference: 10005002-5
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A nutlin-3 analog; inhibits the growth of HCT116 cells at high concentrations (IC50 = ~8 µM); promotes the growth of HCT116 cells ~40% at concentrations between 5-100 nM
Reference: 10005019-1
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An HDAC inhibitor with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate
Reference: 10005019-10
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An HDAC inhibitor with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate
Reference: 10005019-25
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An HDAC inhibitor with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate
Reference: 10005019-5
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An HDAC inhibitor with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate
Reference: 10005031-100
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A relatively non-selective inhibitor of all NOS isoforms with Ki values 0.18, 0.4, and 6 µM for nNOs (rat), eNOS (human), and iNOS (mouse), respectively
Reference: 10005031-25
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A relatively non-selective inhibitor of all NOS isoforms with Ki values 0.18, 0.4, and 6 µM for nNOs (rat), eNOS (human), and iNOS (mouse), respectively
Reference: 10005031-5
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A relatively non-selective inhibitor of all NOS isoforms with Ki values 0.18, 0.4, and 6 µM for nNOs (rat), eNOS (human), and iNOS (mouse), respectively
Reference: 10005031-50
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A relatively non-selective inhibitor of all NOS isoforms with Ki values 0.18, 0.4, and 6 µM for nNOs (rat), eNOS (human), and iNOS (mouse), respectively
Reference: 10005033-10
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A selective antagonist of S1P binding to the S1P3 receptor; blocks calcium increase in HeLa cells by about 40% at 10 µM
Reference: 10005033-25
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A selective antagonist of S1P binding to the S1P3 receptor; blocks calcium increase in HeLa cells by about 40% at 10 µM
Reference: 10005033-5
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A selective antagonist of S1P binding to the S1P3 receptor; blocks calcium increase in HeLa cells by about 40% at 10 µM
Reference: 10005033-50
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A selective antagonist of S1P binding to the S1P3 receptor; blocks calcium increase in HeLa cells by about 40% at 10 µM
Reference: 10005067-1
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A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes
Reference: 10005067-10
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A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes
Reference: 10005067-5
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A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes
Reference: 10005067-50
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A selective inhibitor of the 20-HETE synthase, CYP4A11, exhibiting an IC50 values of 8.8 nM when tested in human renal microsomes
Reference: 10005072-1
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A labeled analog of AEA that is non-fluorescent when outside the cell but upon transport into the cell, is cleaved by esterases to give a bright fluorescence at 530 nm; used as an alternative substrate to study AEA...
Reference: 10005072-100
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A labeled analog of AEA that is non-fluorescent when outside the cell but upon transport into the cell, is cleaved by esterases to give a bright fluorescence at 530 nm; used as an alternative substrate to study AEA...
Reference: 10005072-500
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A labeled analog of AEA that is non-fluorescent when outside the cell but upon transport into the cell, is cleaved by esterases to give a bright fluorescence at 530 nm; used as an alternative substrate to study AEA...
Reference: 10005102-1
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A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM); exhibited IC50 values of 0.81, 83 nM, and 50 µM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine...
Reference: 10005102-10
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A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM); exhibited IC50 values of 0.81, 83 nM, and 50 µM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine...
Reference: 10005102-5
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A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM); exhibited IC50 values of 0.81, 83 nM, and 50 µM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine...
Reference: 10005102-500
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A selective, potent inhibitor of rat FAAH (Ki = 0.57 nM); exhibited IC50 values of 0.81, 83 nM, and 50 µM for FAAH, TGH, and an uncharacterized hydrolase (KIAA1363), respectively, when screened against the serine...
Reference: 10005166-100
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An isoflavone; binds to ERβ (Ki = 2.8 µM) but not ERα up to 1 mM; estrogenic in vitro, increasing ERE-mediated gene transcription via ERβ (EC50 = 2.8 µM); an inhibitor of CAVII and CAXII (Kis = 4.2 and 56 nM,...
Reference: 10005166-1
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An isoflavone; binds to ERβ (Ki = 2.8 µM) but not ERα up to 1 mM; estrogenic in vitro, increasing ERE-mediated gene transcription via ERβ (EC50 = 2.8 µM); an inhibitor of CAVII and CAXII (Kis = 4.2 and 56 nM,...
Reference: 10005166-500
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An isoflavone; binds to ERβ (Ki = 2.8 µM) but not ERα up to 1 mM; estrogenic in vitro, increasing ERE-mediated gene transcription via ERβ (EC50 = 2.8 µM); an inhibitor of CAVII and CAXII (Kis = 4.2 and 56 nM,...
Reference: 10005166-5
€0.00 (tax incl.)
An isoflavone; binds to ERβ (Ki = 2.8 µM) but not ERα up to 1 mM; estrogenic in vitro, increasing ERE-mediated gene transcription via ERβ (EC50 = 2.8 µM); an inhibitor of CAVII and CAXII (Kis = 4.2 and 56 nM,...
Reference: 10005167-100
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An isoflavonoid phytoestrogen with kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties; inhibits EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively);...
Reference: 10005167-1
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An isoflavonoid phytoestrogen with kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties; inhibits EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively);...
Reference: 10005167-250
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An isoflavonoid phytoestrogen with kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties; inhibits EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively);...
Reference: 10005167-500
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An isoflavonoid phytoestrogen with kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties; inhibits EGFR, pp50v-Src, and pp110gag-fes (IC50s = 6, 7-8, and 6.5 µg/ml, respectively);...
Reference: 10005169-10
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A flavonoid; reduces autophagy, decreases the levels of ROS and MDA content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy at 5-100 mg/kg; reduces tumor growth in...
Reference: 10005169-100
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A flavonoid; reduces autophagy, decreases the levels of ROS and MDA content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy at 5-100 mg/kg; reduces tumor growth in...
Reference: 10005169-5
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A flavonoid; reduces autophagy, decreases the levels of ROS and MDA content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy at 5-100 mg/kg; reduces tumor growth in...
Reference: 10005169-50
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A flavonoid; reduces autophagy, decreases the levels of ROS and MDA content, and increases total antioxidant capacity in the kidney in a mouse model of cadmium-induced autophagy at 5-100 mg/kg; reduces tumor growth in...
Reference: 10005174-1
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A lignan with diverse biological activities; reduces LPS-induced production of NO and PGE2 in RAW 264.7 cells; cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml); increases the lifespan of C. elegans at 100 µM;...
Reference: 10005174-10
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A lignan with diverse biological activities; reduces LPS-induced production of NO and PGE2 in RAW 264.7 cells; cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml); increases the lifespan of C. elegans at 100 µM;...
Reference: 10005174-25
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A lignan with diverse biological activities; reduces LPS-induced production of NO and PGE2 in RAW 264.7 cells; cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml); increases the lifespan of C. elegans at 100 µM;...
Reference: 10005174-5
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A lignan with diverse biological activities; reduces LPS-induced production of NO and PGE2 in RAW 264.7 cells; cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml); increases the lifespan of C. elegans at 100 µM;...
Reference: 10005186-10
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A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner;...
Reference: 10005186-25
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A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner;...
Reference: 10005186-5
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A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner;...
Reference: 10005186-50
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A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner;...
Reference: 10005189-1
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Suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes; increases chemo- or radiosensitivity of tumors
Reference: 10005189-10
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Suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes; increases chemo- or radiosensitivity of tumors
Reference: 10005189-25
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Suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes; increases chemo- or radiosensitivity of tumors
Reference: 10005189-5
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Suppresses both constitutive and hypoxia-induced levels of HIF-1α in cancer cells, resulting in reduced expression of HIF-1α target genes; increases chemo- or radiosensitivity of tumors
Reference: 10005229-10
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A proapoptoic compound with selectivity for cancer cells; induces apoptosis in vitro in various cancer cell lines (IC50 = 0.89-2.69 µM)
Reference: 10005229-5
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A proapoptoic compound with selectivity for cancer cells; induces apoptosis in vitro in various cancer cell lines (IC50 = 0.89-2.69 µM)
Reference: 10005229-50
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A proapoptoic compound with selectivity for cancer cells; induces apoptosis in vitro in various cancer cell lines (IC50 = 0.89-2.69 µM)
Reference: 10005254-1
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A melatonin metabolite first identified in rat brain that has antioxidant and free radical scavenging activities in several experimental models; may be measured in plasma as an index of melatonin synthesis and...
Reference: 10005254-10
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A melatonin metabolite first identified in rat brain that has antioxidant and free radical scavenging activities in several experimental models; may be measured in plasma as an index of melatonin synthesis and...
Reference: 10005254-5
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A melatonin metabolite first identified in rat brain that has antioxidant and free radical scavenging activities in several experimental models; may be measured in plasma as an index of melatonin synthesis and...
Reference: 10005254-50
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A melatonin metabolite first identified in rat brain that has antioxidant and free radical scavenging activities in several experimental models; may be measured in plasma as an index of melatonin synthesis and...
Reference: 10005263-10
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An inhibitor of fatty acid synthesis that blocks the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC)
Reference: 10005263-100
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An inhibitor of fatty acid synthesis that blocks the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC)
Reference: 10005263-5
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An inhibitor of fatty acid synthesis that blocks the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC)
Reference: 10005263-50
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An inhibitor of fatty acid synthesis that blocks the synthesis of malonyl-CoA by acetyl-CoA carboxylase (ACC)
Reference: 10005270-1
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A stable inhibitor of FASN that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice
Reference: 10005270-10
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A stable inhibitor of FASN that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice
Reference: 10005270-5
€0.00 (tax incl.)
A stable inhibitor of FASN that leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice

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