Fz7-21 TFA Reference: HY-P1454A Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) TFA is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 TFA impairs the function of FZD7 in Wnt-β-catenin signalling and stem cell function in intestinal organoids.
Arg-Gly-Glu-Ser Reference: HY-P0309 Arg-Gly-Glu-Ser is a RGD-related peptide and a control for the RGDS ihibitory activity on fibrinogen binding to activated platelets.
CooP Reference: HY-P4115 CooP is a linear glioblastoma-targeting nonapeptide. CooP binds to the mammary-derived growth inhibitor/fatty acid binding protein 3 (FABP3) in the glioblastoma cells and its associated vasculature. CooP is used for the targeted delivery of chemotherapy and different nanoparticles.
Gly-Arg-Gly-Asp-Ser Reference: HY-P0295 Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM
β-Amyloid (1-40) Reference: HY-P0265 β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease.
β-catenin peptide Reference: HY-P1589 β-catenin peptide is a 8-aa peptide, and can promote thymocyte positive selection.