RGDV Reference: HY-P3052 RGDV is a platelet aggregation inhibitor. RGDV inhibits platelet-dependent thrombus formation. RGDV is used for tumor recognition via the targeting effect.
[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) Reference: HY-P1776 [pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) binds to insulin and can be used as insulin receptor tyrosine kinase substrates.
Human MLC1SA protein, His tag Reference: GTX57345-pro Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 21]
Onvitrelin ucalontide Reference: HY-P4144 Onvitrelin ucalontide ([Phor18-LHRH (338613)]) is an analogue of luteinizing hormone releasing hormone (LHRH) with antineoplastic activity. Onvitrelin ucalontide is a peptide with sequences of KFAKFAKKFAKFAKKFAKQHWSYGLRPG. Onvitrelin ucalontide effectively inhibits breast cancer, ovarian cancer and prostate cancer xenografts in mouse model.
SAH-SOS1A TFA Reference: HY-P2265A SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). SAH-SOS1A TFA directly and independently blocks nucleotide association. SAH-SOS1A TFA impairs KRAS-driven cancer cell viability and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.
Human NEK7 protein, His tag Reference: GTX57347-pro NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans never in mitosis A gene, which controls initiation of mitosis.[supplied by OMIM, Jul 22]
Autocamtide 2, amide Reference: HY-P1528 Autocamtide 2, amide is a substrate (100 μM final concentration) for CaMK family assays.
Z-LEHD-FMK TFA Reference: HY-P1010A Z-LEHD-FMK TFA is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal cord trauma.