PODS® Human NT-4 Reference: PPH33-250 The product contains the polyhedrin protein co-crystalized with Human NT-4. Neurotrophin-4 (NT-4), also known as NT-5, is a neurotrophic factor and a member of the NGF family. NT-4 is expressed in the prostate, thymus, placenta, and skeletal muscle. NT-4 promotes the development and survival of peripheral and CNS neurons and the proliferation of keratinocyte.
SRD5A2 blocking peptide Reference: GTX89611-PEP This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 28]
PODS® Human NT-4 Reference: PPH33-1000 The product contains the polyhedrin protein co-crystalized with Human NT-4. Neurotrophin-4 (NT-4), also known as NT-5, is a neurotrophic factor and a member of the NGF family. NT-4 is expressed in the prostate, thymus, placenta, and skeletal muscle. NT-4 promotes the development and survival of peripheral and CNS neurons and the proliferation of keratinocyte.
XAGE1 (Isoform 1d)/GAGED2 blocking peptide Reference: GTX89612-PEP This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 21]
PODS® Human OPN Reference: PPH319-50 The product contains the polyhedrin protein co-crystalized with Human OPN. Osteopontin (OPN) is a secreted molecule in the SIBLING (small integrin-binding ligand N-linked glycoprotein) family of non-collagenous matricellular proteins. OPN is widely expressed and is prominent in mineralized tissues, inhibiting bone mineralization and kidney stone formation. This growth factor promotes inflammation, cell adhesion, and migration. Moreover its expression is up‑regulated during inflammation, obesity, atherosclerosis, cancer, and tissue damage.
PODS® Human OPN Reference: PPH319-250 The product contains the polyhedrin protein co-crystalized with Human OPN. Osteopontin (OPN) is a secreted molecule in the SIBLING (small integrin-binding ligand N-linked glycoprotein) family of non-collagenous matricellular proteins. OPN is widely expressed and is prominent in mineralized tissues, inhibiting bone mineralization and kidney stone formation. This growth factor promotes inflammation, cell adhesion, and migration. Moreover its expression is up‑regulated during inflammation, obesity, atherosclerosis, cancer, and tissue damage.
ERK2/MAPK1 blocking peptide Reference: GTX89615-PEP The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jul 28]
PODS® Human OPN Reference: PPH319-1000 The product contains the polyhedrin protein co-crystalized with Human OPN. Osteopontin (OPN) is a secreted molecule in the SIBLING (small integrin-binding ligand N-linked glycoprotein) family of non-collagenous matricellular proteins. OPN is widely expressed and is prominent in mineralized tissues, inhibiting bone mineralization and kidney stone formation. This growth factor promotes inflammation, cell adhesion, and migration. Moreover its expression is up‑regulated during inflammation, obesity, atherosclerosis, cancer, and tissue damage.
Caspase 4 blocking peptide Reference: GTX89618-PEP This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 28]
PODS® Human PDGF-AA Reference: PPH16-50 The product contains the polyhedrin protein co-crystalized with Human PDGF-AA. Platelet-Derived Growth Factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells. PDGF is also stored in the α-granules of platelets and is released upon adherence to traumatized tissues. PDGF is a dimeric glycoprotein formed by two A chains (AA), two B chains (BB), or as a heterodimer with an A and a B chain (AB). The PDGF dimer binds the cell surface receptor tyrosine kinases PDGFR-a and PDGFR-b.